Bone metabolism during methylprednisolone pulse therapy in rheumatoid arthritis.
نویسندگان
چکیده
منابع مشابه
Bone metabolism during methylprednisolone pulse therapy in rheumatoid arthritis.
The deleterious effects of corticosteroids (CS) on bone are well known, but probably differ depending on duration and dosage of CS therapy. Presently huge amounts of CS are given over a short period of time in different rheumatic conditions. Not much is known about the effect of this kind of CS treatment on bone metabolism. Twenty patients with persistently active rheumatoid arthritis were trea...
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intravenous glucocorucoid pulse therapy is a common treatment for immunologically origin diseases but it can not be considered a completely bening treatment.the effects of long term administration of glucocorticoids on calcium and phosphorus metabolism are week known ,but is less in known about the effect of pluse therapy.the purpose of this study was to investigate the effect of methylpredn...
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In active RA, bone resorption is increased and bone formation is normal or reduced in comparison to healthy controls. This uncoupling of bone formation and resorption with a negative remodelling balance leads to generalized bone loss. The pathogenesis of this altered bone metabolism is multifactorial, involving non-disease-specific factors (such as age, female sex and postmenopausal status) and...
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Pulsed methylprednisolone (PMP) has been shown to produce clinical improvement and reduction in the ESR and acute phase protein concentrations in patients with active rheumatoid arthritis and has been advocated for use either as an alternative to slow-acting antirheumatoid drugs (SAARDs) or in conjunction with SAARDs to accelerate the response to treatment. To test these potential roles for PMP...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1986
ISSN: 0003-4967
DOI: 10.1136/ard.45.9.757